MINFLUX nanoscopy enhanced with high-order vortex beams

Minimal photon fluxes (MINFLUX) nanoscopy has emerged as a transformative advancement in superresolution imaging, enabling unprecedented nanoscale observations across diverse biological scenarios. A research team led by Associate Professor Huang Zhiwei, Senior Principal Investigator from the Biomedical and Health Technology Research Platform of NUSRI Suzhou, has proposed, for the first time, that employing high-order vortex beams can significantly enhance the performance of MINFLUX, surpassing the limitations of the conventional MINFLUX using the first-order vortex beam. The results were published in the journal Light: Science & Applications.