WU Jie

WU Jie

WU Jie

Senior Investigator

chmjie@nus.edu.sg

Education

2002-2006 Department of Chemistry, Beijing Normal University,B.S.

2006-2012 Department of Chemistry, Boston University,Ph.D.


Work Experience

2012-2015 Department of Chemistry and Chemical Engineering, Massachusetts Institute of Technology,Post-doctoral

2015-2015 Snapdragon Chemistry, Inc. Boston, Senior research scientist          

2015-2021 Department of Chemistry, National University of Singapore,Assistant Professor

2021-Present Department of Chemistry, National University of Singapore,Associate Professor

Research Interests

1. Continuous-flow Synthesis

2. Photochemistry

3. Automated Synthesis


Honor & Award

2017-2019 Asian Core Program Lectureship Award (Korea, Thailand, China)

2018  NUS Chemistry Department Young Chemist Award

2019  Thieme Chemistry Journal Award           

2020 The Distinguished Lectureship Award, The CSJ Asian International Symposium, The Chemical Society of Japan


Representative Publications

[1] Cai, B.; Cheo, H. W.; Liu, T.; Wu, J.*Light-promoted Carbon-Carbon Bond Formation Utilizing Natural Gases as FeedstocksAngew. Chem. Int. Ed. 2020, accepted. DOI: 10.1002/anie.202010710

[2] Wang, H.; Toh, R. W.; Shi, X.; Wang, T.; Cong, X.; Wu, J.*Photo-mediated Selective Deconstructive Geminal Dihalogenation of Trisubstituted AlkenesNat. Commun. 2020, 11, 4462

[3] Kuang, Y.; Cao, H.; Tang, H.; Chew, J.; Chen, W.; Shi, X.; Wu, J.*Visible Light Driven Deuteration of Formyl C-H and Hydridic C(sp3)-H Bonds in Feedstock Chemicals and Pharmaceutical MoleculesChem. Sci. 2020, 11, 8912-8918

[4] Yan, J.; Cheo, H. W.; Teo, W. K.; Shi, X.; Wu, H.; Idres, S. B.; Deng. L.-W.; Wu, J.*A Radical Smiles Rearrangement Promoted by Neutral Eosin Y as a Direct Hydrogen Atom Transfer PhotocatalystJ. Am. Chem. Soc. 2020, 142, 11357-11362 (Highlighted by Rational Science and X-MOL)

[5] Zhang, Y.; Yang, X.; Wu, J.*; Huang, D.* “Aerobic C-H Functionalization Using Pyrenedione as the PhotocatalystSynthesis 2020, DOI: 10.1055/s-0040-1707135

[6] Zheng, L.; Xue, H.; Wong, W. K.; Cao, H.; Wu, J.*; Khan, A. S.* “Cloud-inspired Multiple Scattering for Light Intensified Photochemical Flow ReactorsReact. Chem. Eng. 2020, 5, 1058-1063

[7] Jia, P.; Li, Q.; Poh, W. C.; Jiang, H.; Liu, H.; Deng, H.; Wu, J.*Light-Promoted Bromine Radicl-Mediated Selective Alkylation and Amination of Unactivated C(sp3)-H BondsChem 2020, 6, 1766-1776

[8] Cao, H.; Kuang, Y.; Shi, X.; Wong, K. L.; Tang, B. B.; Kwan, J. M. C.; Liu, X.; Wu, J.*Photoinduced Site-Selective Alkenylation of Alkanes and Aldehydes with Aryl AlkenesNat. Commun. 2020, 11, 1956 (Highlighted by Synfacts 2020, 16, 0795 and chosen as Synfacts of the month. It has been higlighted by iCat, Phys. Org, Organic Chemistry Portal, and National University of Singapore (Suzhou) Research Institute)

[9] Xu, W.; Jiang, H.; Leng, J.; Ong, H.-W.; Wu, J.*Visible-Light-Induced Selective Defluoroborylation of Polyfluoroarenes, gem-Difluoroalkenes, and TrifluoromethylalkenesAngew. Chem. Int. Ed. 2020, 59, 4009-4016 (Highlighted by Rational Science and X-MOL)

[10] Zhang, Y.; Yang, X.; Tang, H.; Liang, D.; Wu, J.*, Huang, D.* “Pyrenediones as Versatile Photocatalysts for Oxygenation Reactions with in situ Generation of Hydrogen Peroxide under Visible LightGreen Chem. 2020, 22, 22-27

[11] Liu, R.; Chia, S. P. M.; Goh, Y. Y.; Cheo, H. W.; Fan, B.; Li, R.; Zhou, R.*; Wu, J.*Visible‐Light‐Mediated Regioselective Allylation, Benzylation, and Silylation of Methylene‐Malononitriles via Photoredox‐Induced Radical Cation FragmentationEur. J. Org. Chem. 2020, 10, 1459-1465

[12] Kuang, Y.; Wang, K.; Shi, X.; Huang, X.; Meggers, E.; Wu, J.*Asymmetric Synthesis of 1,4‐Dicarbonyl Compounds from Aldehydes via the Marriage of Hydrogen Atom Transfer Photocatalysis with Chiral Lewis Acid CatalysisAngew. Chem. Int. Ed. 2019, 58, 16859-16863 (Highlighted by WeeChem and X-MOL)

[13] Fan, X.; Xiao, P.; Jiao, Z.; Yang, T.; Dai, X.; Xu, W.; Tan, J. D.; Cui, G.*, Su, H.; Fang, W.; Wu, J.*Neutral-Eosin-Y-Photocatalyzed Silane Chlorination Using DichloromethaneAngew. Chem. Int. Ed. 2019, 58, 12580 (Highlighted by X-MOL)

[14] Zhou, R.; Li, J.; Cheo, H. W.; Chua, R.; Zhan, G.; Hou, Z.; Wu, J.*Visible-Light-Mediated Deuteration of Silanes with Deuterium OxideChem. Sci. 2019, 10, 7340-7344 (Featured as back cover in Chemical Science)

[15] Xu, J.-H.; Wu, W.-B.; Wu, J.*Photoinduced Divergent Alkylation/Acylation of Pyridine N-Oxides with Alkynes under Anaerobic and Aerobic ConditionsOrg. Lett. 2019, 21, 5321-5325

[16] Ou, W.; Zhang, G.; Wu, J.; Su, C.* “Photocatalytic Cascade Radical Cyclization Approach to Bioactive Indoline-Alkaloids over Donor-Acceptor Type Conjugated Microporous PolymerACS Catal. 2019, 9, 5178-5183

[17] Wong, Y.-C.; Wu, W.-B.; Wang, T.; Ng, J. D. A.; Khoo, K. H.*; Wu, J.*; Tan, Z.-K.* "Color Patterning of Luminescent Perovskites via Light‐Mediated Halide Exchange with Haloalkanes" Adv. Mater. 2019, 31, 1901247

[18] Wu, J.*Young Career Focus: Dr. Jie Wu (National University of Singapore, Singapre).” Synform 2019, 05, A68-A70

[19] Ng. C. K.; Toh, R. W.; Lin, T. T.; Luo, H.; Hor, T. S. A.*; Wu, J.*Metal-Salen Molecular Cages as Efficient and Recyclable Heterogeneous Catalysts for Cycloaddition of CO2 with Epoxides at Ambient Conditions.” Chem. Sci. 2019, 10, 1549-1554 (Highlighted by Synfacts 2019, 15, 0540)

[20] Li, J.; Luo, Y.; Cheo, H. W.; Lan, Y.*; Wu, J.*Photoredox Catalysis Modulated Nickel-Catalyzed Divergent Difunctionalization of EthyleneChem 2019, 5, 192 (Highlighted by X-MOL, NUS FoS, and Phys.Org)

[21] Xue, C.; Li, J.; Lee, J. P.; Zhang, P.*; Wu, J.*Continuous Amination of Aryl/Heteroaryl Halides Using Aqueous Ammonia in a Teflon AF-2400 Tube-in-Tube Micro-Flow Reactor.” React. Chem. Eng. 2018, 4, 346-350 (Invited article for special issue “RCE Emerging Investigator 2019”)

[22] Cao, H.; Jiang, H.; Feng, H.; Kwan, J.; Liu, X.; Wu, J.*Photo-Induced Decarboxylative Heck-Type Coupling of Unactivated Aliphatic Acids and Terminal Alkenes in the Absence of Sacrificial Hydrogen Acceptors.” J. Am. Chem. Soc. 2018, 140, 16360-16367 (Highlighted by Synfacts 2019, 15, 0159; Org. Process Res. Dev. 2019, 23, 114-121; and X-MOL)

[23] Hou, J.; Ee, A.; Cao, H.; Ong, H.-W.; Xu, J.-H.; Wu, J.*Visible-Light-Mediated Metal-Free Difunctionalization of Alkenes with CO2 and Silanes or C(sp3)-H Alkanes.” Angew. Chem. Int. Ed. 2018, 57, 17220-17224 (Selected as VIP paper in Angew. Chem. Int. Ed.; Highlighted by Synfacts 2019, 15, 0198 and X-MOL, and WeeChem)

[24] Deng, H. P.; Zhou, Q.; Wu, J.*Micro-Tubing Reactor-Assisted Aliphatic C-H Functionalization Utilizing HCl as the Hydrogen Atom Transfer Catalyst Precursor in Conjunction with an Organo Photoredox Catalyst.” Angew. Chem. Int. Ed. 2018, 57, 12661-12665 (Highlighted by Synfacts 2018, 14, 1322 and X-MOL)

[25] Wu, W. B.; Wong, Y. C.; Tan, Z. K.*; Wu, J.*Photo-Induced Thiol Coupling and C-H Activation Using Nanocrystalline Lead-Halide Perovskite Catalysts.” Catal. Sci. Technol. 2018, 8, 4257-4263

[26] Li, J. S.; Wu, J.*Recent Development of Photo-Mediated Generation of Silyl Radicals and Their Application in Organic Synthesis.” ChemPhotoChem 2018, 2, 839-846 (Invited Review)

[27] Liu, H.; Ma, L.; Zhou, R.; Chen, X.*; Fang, W.; Wu, J.*One-Pot Photo-Mediated Giese Reaction/Friedel-Crafts Hydroxyalkylation/Oxidative Aromatization to Access Naphthalene Derivatives from Toluenes and Enones.” ACS Catal. 2018, 8, 6224-6229 (Highlighted by X-MOL)

[28] Hou, J.; Li, J.; Wu, J.*Recent Development of Light-Mediated Carboxylation Using CO2 as the Feedstock.” Asian J. Org. Chem. 2018, 7, 1439-1447 (Invited Review)

[29] Fan, X.; Rong, J.; Wu, H.; Zhou, Q.; Deng, H.; Tan, J. D.; Xue, C.; Wu, L,; Tao, H.; Wu, J.*Eosin Y as a Direct Hydrogen Atom Transfer Photocatalyst for the Functionalization of C-H Bonds.” Angew. Chem. Int. Ed. 2018, 57, 8514-8518 (Highlighted by Angew. Chem. Int. Ed. 2019, 58, 378)

[30] Hou, J.; Ee, A.; Feng, W.; Xu, J.; Zhao, Y.*; Wu, J.*Visible-Light-Driven Alkyne Hydro-/Carbocarboxylation Using CO2 via Iridium/Cobalt Dual Catalysis for Divergent Heterocycle Synthesis.” J. Am. Chem. Soc. 2018, 140, 5257-5263 (Highlighted by X-MOL, featured in Organic Chemistry Portal)

[31] Toh, R. W.; Li, J. S.; Wu, J.*Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations.” J. Vis. Exp. 2018, 131, e56897

[32] Zhou, R.; Goh, Y. Y.; Liu, H.; Tao, H.; Li, L.; Wu, J.*Visible-Light-Mediated Metal-Free Hydrosilylation of Alkenes through Selective Hydrogen Atom Transfer for Si-H ActivationAngew. Chem. Int. Ed. 2017, 56, 16621-16625 (Highlighted in Synfacts 2018, 14, 0819 and X-MOL)

[33] Deng, H.; Fan, X.; Chen, Z.; Xu, Q.; Wu, J.*Photo-Induced Nickel-Catalyzed Chemo- and Regioselective Hydroalkylation of Internal Alkynes with Ether and Amide a-Hetero C(sp3)-H BondsJ. Am. Chem. Soc. 2017, 139, 13579-13584 (Highlighted by X-MOL, NUS FoS, and Phys.org)

[34] Zhou, R.; Liu, H.; Tao, H.; Yu, X.; Wu, J.*Metal-Free Direct Alkylation of Unfunctionalized Allylic/Benzylic sp3 C-H bonds via Photoredox Induced Radical Cation DeprotonationChem. Sci. 2017, 8, 4654-4659 (Highlighted in Synfacts 2017, 13, 0819; most downloaded articles of 2017 in Chem. Sci.)

[35] Xue, F.; Deng, H.; Xue, C.; Mohamed, D. K. B.; Tang, K. Y.; Wu, J.*Reaction Discovery Using Acetylene Gas as the Chemical Feedstock Accelerated by the ‘Stop-Flow’ Micro-Tubing Reactor SystemChem. Sci. 2017, 8, 3623-3627

[36] Ng. C. K.; Wu, J.*; Hor, T. S.;* Luo, H.*“A Binary Catalyst System of a Cationic Ru-CNC Pincer Complex with an Alkali Metal Salt for Selective Hydroboration of Carbon Dioxide Chem. Commun. 2016, 52, 11842-11845

[37] Mohamed, D. K. B.; Yu, X.; Li, J.; Wu, J.*Reaction Screening in Continuous Flow ReactorsTetrahedron Lett. 2016, 57, 3965-3977 (Invited Review)


Patents

1. Wu, J.; Khan, A. S.; Liu, C.; Wu, W.; Chen, W.; Wang, M.; Xie, J. “Method and System for Synthesising Compounds” US Provisional Patent Application No. 62/925,031.

2. Wu, J.; Li, J.; Xue, C.; Mohamed D. “Lotus-Type Reactor for Large-Scale Continuous-Flow and Stop-Flow Synthesis” Application No. 10201700300X.

3. Wu, J.; Deng H.; Xue, F.; Mohamed, D. “Modular ‘Stop-Flow’ Parallel Microtubing Reactor Platform Useful for High-Pressure Reaction Screening” US 62/320726.


Other Investigators

CHEN Wei
CHEN Wei

Principal Investigator

chmcw@nus.edu.sg
CHEN Jingsheng
CHEN Jingsheng

Principal Investigator

msecj@nus.edu.sg
CHIN Wee Shong
CHIN Wee Shong

Senior Investigator

chmcws@nus.edu.sg
LEE Heow Pueh
LEE Heow Pueh

Senior Investigator

mpeleehp@nus.edu.sg
LIN Man-Hua
LIN Man-Hua

Adjunct Principal Investigator

mandy.lin@nusri.cn
LU Li
LU Li

Principal Investigator

luli@nus.edu.sg
LIU Xiao Gang
LIU Xiao Gang

Principal Investigator

chmlx@nus.edu.sg
LU Yixin
LU Yixin

Principal Investigator

chmlyx@nus.edu.sg
NG How Yong
NG How Yong

Principal Investigator

ceenghy@nus.edu.sg
OUYANG Jianyong
OUYANG Jianyong

Senior Investigator

mseoj@nus.edu.sg
WANG Qing
WANG Qing

Senior Investigator

qing.wang@nus.edu.sg
XU Dong
XU Dong

Associate Investigator
Centre Research Director

erixd@nus.edu.sg
XIE Xianning
XIE Xianning

Senior Investigator

xn.xie@nusri.cn
XU Guoqin
XU Guoqin

Principal Investigator

guoqin.xu@nusri.cn
XU Qinghua
XU Qinghua

Senior Investigator
Centre Director

chmxqh@nus.edu.sg