LU Yixin

LU Yixin

LU Yixin

Principal Investigator

chmlyx@nus.edu.sg
Education

1987-1991 Department of Materials Science, Fudan University, B.Sc.

1995-2000 Department of Chemistry, McGill University, Ph.D.


Professional Experiences

2003-2010 Department of Chemistry, National University of Singapore, Assistant Professor

2010-2014 Department of Chemistry, National University of Singapore, Associate Professor

2014-Present Department of Chemistry, National University of Singapore,Professor

2016-Present NUS Research Institute in Suzhou, Principal Investigator


Honor & Award

2013 GSK-SNIC Award in Organic Chemistry

2018 Singapore National Research Foundation (NRF) Investigatorship Award


Representative Publications (out of >150 publications, with >7,200 citations, and h-index 51)           

[1] Bai, X.; Wu, C.; Ge, S.; Lu, Y.Pd/Cu-Catalyzed Enantioselective Sequential Heck-Sonogashira Coupling: Asymmetric Synthesis of Oxindoles Containing Trifluoromethylated Quaternary Stereogenic Centers Centers”, Angew. Chem. Int. Ed., 2020, 59, 2764.

[2] Mei, G.-J.; Tang, X.; Tasdan, Y.; Lu, Y.Enantioselective Dearomatization of Indoles by an Azoalkene-Enabled (3+2) Reaction: Access to Pyrroloindolines”, Angew. Chem. Int. Ed. 2020, 58, 648.

[3] Wu, M.; Han, Z.; Li, K.; Wu, J.; Ding, K. Lu, Y.Cyclohexyl-Fused, Spirobiindane-derived, Phosphine-catalyzed Synthesis of Tricyclic γ-Lactams and Kinetic Resolution of γ-Substituted Allenoates”, J. Am. Chem. Soc., 2019, 141, 16362.

[4] Chan, W.-L.; Tang, X.; Zhang, F.; Quek, G.; Mei, G.-J.; Lu, Y.Phosphine-Catalyzed (3+2) Annulation of Isoindigos with Allenes: Enantioselective Formation of Two Vicinal Quaternary Stereogenic Centers”, Angew. Chem. Int. Ed. 2019, 58, 6260。

[5] Li, K.; Gonçalves, T. P.; Huang, K.-W.; Lu, Y.Dearomatization of 3-Nitroindoles by a Phosphine-catalyzed Enantioselective [3+2] Annulation Reaction”, Angew. Chem. Int. Ed. 2019, 58, 5427.

[6] Ni, H.; Chan, W.-L.; Lu, Y.Phosphine-catalyzed Asymmetric Organic Reactions”, Chem. Rev. 2018, 118, 9344.  

[7] Ni, H.; Tang, X.; Zheng, W.; Yao, W.; Ullah, N.; Lu, Y.Enantioselective Phosphine-Catalyzed Formal [4+4] Annulation of a,b-Unsaturated Imines and Allene Ketones: Construction of Eight-membered Rings”, Angew. Chem. Int. Ed. 2017, 56, 14222.

[8] Yao, W.; Dou, X.; Wen, S.; Wu, J.; Vittal, J. J.; Lu, Y.Enantioselective Desymmetrization of Cyclohexadienones via an Intramolecular Rauhut–Currier Reaction of Allenoates”, Nat. Commun. 2016, 7, 13024.

[9] Wang, T.; Han, X.; Zhong, F.; Yao, W.; Lu, Y.Amino Acid-derived Bifunctional Phosphines for Enantioselective Transformations”, Acc. Chem. Res. 2016, 49, 1369.

[10] Wang, T.; Yu, Z.; Hoon, D. L.; Phee, C. Y.; Lan, Y.; Lu, Y.Regiodivergent Enantioselective g-Additions of Oxazolones to 2,3-Butadienoates Catalyzed by Phosphines: Synthesis of a,a-Disubstituted a-Amino Acids and N,O-Acetal Derivatives”, J. Am. Chem. Soc. 2016, 138, 265.

Other Investigators

GUO Yongxin
GUO Yongxin

Principal Investigator
Centre Director

yongxin.guo@nus.edu.sg
KAM Pooi-Yuen
KAM Pooi-Yuen

Principal Investigator

py.kam@nus.edu.sg
LIAN Yong
LIAN Yong

Principal Investigator

yong.lian@nusri.cn
LIN Fujiang
LIN Fujiang

Adjunct Principal Investigator

QIU Cheng Wei
QIU Cheng Wei

Senior Investigator

chengwei.qiu@nusri.cn
YANG Shining
YANG Shining

Adjunct Principal Investigator

Yung C. LIANG
Yung C. LIANG

Senior Investigator

yc.Liang@nusri.cn
YU Haoyong
YU Haoyong

Senior Investigator

bieyhy@nus.edu.sg
ZHANG Naiqian
ZHANG Naiqian

Adjunct Principal Investigator

ZHOU Meisheng
ZHOU Meisheng

Adjunct Principal Investigator

HUANG Zhiyong
HUANG Zhiyong

Senior Investigator

dcshuang@nus.edu.sg
ZHOU Zhiying
ZHOU Zhiying

Senior Investigator

zhiying.zhou@nusri.cn
CHEN Jingsheng
CHEN Jingsheng

Principal Investigator

msecj@nus.edu.sg
CHIN Wee Shong
CHIN Wee Shong

Senior Investigator

chmcws@nus.edu.sg
LIU Xiao Gang
LIU Xiao Gang

Principal Investigator

chmlx@nus.edu.sg